Vitamin B12 Deficiency Can Lead to Childhood Brain Damage
This is very important information for anybody who’s trying to get pregnant. Eating enough foods rich in Vitamin B12 is vital for a healthy baby.
New research published in this month’s Pediatrics suggests women with low levels of Vitamin B12 just before or after conception are more likely to give birth to children with neural tube defects, according to the National Institutes of Health, Trinity College Dublin, and the Health Research Board of Ireland.
This research, however, is a reminder that pregnant women, particularly, must take special care to fortify themselves with all the nutrients their developing babies need.
Here’s a look at the National Institutes of Health description of the new research:
To conduct the study, the researchers analyzed stored blood samples originally collected during early pregnancy from three groups of Irish women between 1983 and 1990. During that time, pregnant women in Ireland rarely took vitamin supplements. The study authors reasoned that the lack of routine vitamin supplementation would allow them to identify a sufficient number of women with low Vitamin B12 to conduct their analysis.
For their analysis, the researchers classified the women into three groups. The first group consisted of 95 women who were pregnant with a child having a neural tube defect at the time the blood was taken. The second group was composed of 107 women who had previously given birth to a child with a neural tube defect but whose current pregnancy was not affected. Like the first group, women in the third group (a total of 76) were pregnant with a child having a neural tube defect at the time the blood sample was obtained, but were enrolled in a different study than the women in group 1. The researchers measured the Vitamin B12 and folate levels of the women’s blood samples, and compared them to those of control groups whose pregnancies were unaffected by a neural tube defect.
Because low folate levels are a known risk factor for neural tube defects, the researchers used statistical techniques to evaluate the role of Vitamin B12 independently of the role of folate. In all three groups, women with low B12 concentrations (estimated at less than 250 ng/L, before pregnancy) had 2.5-3 times the risk of having a child with a neural tube defect compared to those with higher levels. Women with levels in the deficient range (0-149 ng/L ) were at the highest risk: 5 times that of women with higher levels.
The study authors wrote that it is not known how B12 and folate might interact to influence the formation of the neural tube, the embryonic structure that gives rise to the spine and brain. They noted that the two vitamins are jointly involved with several key biochemical reactions, as well as with the synthesis of DNA. Lack of either Vitamin B12 or folate in any of these chemical processes theoretically could increase the risk of a neural tube defect.
The authors noted that their results needed to be confirmed by other studies among other populations of women. They suggested, however, that women should have Vitamin B12 levels above 300 ng/L before becoming pregnant. (Because B12 levels drop sharply during pregnancy, the researchers adjusted the levels measured during pregnancy to provide a target level for women to achieve before they become pregnant.)
Found at http://www.thedailygreen.com/healthy-eating/eat-safe/vitamin-b12-pregnancy-47030203
